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This paper aims to examine the role of technological Innovation in ensuring resource sustainability in the water, energy and food (WEF) nexus, as there exists a shortage of statistical research on the extent of the influence of technological Innovation on the WEF nexus.

The study used a quantitative research method, using a well-structured questionnaire to collect data from management staff in the WEF departments in South Africa. The collected data were analyzed by using mean score ranking, exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) for structural equation modelling (SEM).

The findings show that the technological process of technological innovation is significant for resource sustainability. The result also showed that technological innovations directly and statistically significantly affect WEF nexus. The EFA resulted in three components of WEF nexus product innovation, WEF nexus process innovation and WEF nexus novel innovations. Furthermore, the CFA and SEM analysis reveals that six technological innovation indicators influence the sustainability of the nexus: smart water metering technology, smart metering technology, food quality monitoring technology, agricultural technology solutions, new technological design and eco-friendly WEF products.

The sustainability of these three inevitable resources for man’s survival is dependent on technological innovations, and this study has shown the major categories of innovations needed, thus establishing a pathway for engineering design.

The unseen benefit of the COVID-19 pandemic in Nigeria is that it presented an insight into the contributions of the manufacturing industry to the socio-economic development of the nation. During the pandemic, the unavailability of Personal Protective Equipment (PPE) have demonstrated the low production capability of the Nigerian manufacturing industry to provide essential materials and equipment required by the health sector. This availability of these facilities is vital for the sustenance of public health and lives of frontline health workers. Consequently, this challenge resulted in an increase in infection and deaths of frontline health workers which could have minimized if there were adequate provision of PPE local production. Hence, this study postulates that the COVID-19 pandemic is an entrepreneurial opportunity in Nigeria, especially for the mass production of PPE to service the health sector of Nigeria and sub-Saharan Africa. The study therefore investigated the challenges of entrepreneurship in Nigeria's manufacturing industry and examined how the strategic partnership between educational institutions, corporate bodies and the government can be optimized. Utilizing a qualitative research methodology based on scholarly journals and interview sessions, the study revealed that Nigeria's manufacturing capability is low due to Nigeria's age-long protectionist tendency, lack of integration of entrepreneurship skill in the industry, inadequate knowledge of financial knowledge, lack of synergy in the industry, among others. The study recommended a strategic framework for Nigeria's manufacturing industry for the production of PPE in form of a helix model after an overhauling of the production process of the industry.